Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 16/20 | 0.55 |
| ▸ | PDE4A | P27815 | 4/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222740 | 0.99 | PGR (0.55) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3518152 | 0.86 | PGR (0.72) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3521249 | 0.84 | PGR (0.61) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7128459 | 0.82 | PGR (0.44) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5230464 | 0.81 | PGR (0.53) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6408891 | 0.76 | PGR (0.73) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6433927 | 0.75 | PGR (0.72) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3521215 | 0.75 | PGR (0.56) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3522548 | 0.73 | PGR (0.56) | PGRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3990700 | 0.73 | PGR (0.58) | PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476262-B2 | Cyanopyrroles | WYETH LLC (US) | 2013-07-02 | — | — | US | disclosed |
| US-20110039839-A1 | Cyanopyrroles | WYETH LLC (US) | 2011-02-17 | — | — | US | disclosed |
| US-7846924-B2 | Cyanopyrroles | WYETH LLC (US) | 2010-12-07 | — | — | US | disclosed |
| US-7645761-B2 | Indoline derivatives | WYETH (US) | 2010-01-12 | — | — | US | disclosed |
| US-20070259944-A1 | Indoline derivatives | WYETH (US) | 2007-11-08 | — | — | US | disclosed |
| US-7253203-B2 | Indoline derivatives | WYETH (US) | 2007-08-07 | — | — | US | disclosed |
| EP-1175398-B1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | WYETH CORP (US) | 2007-07-11 | — | — | EP | disclosed |
| US-7091234-B2 | Thio-oxindole derivatives | WYETH (US) | 2006-08-15 | — | — | US | disclosed |
| US-7084168-B2 | Indoline derivatives | WYETH (US) | 2006-08-01 | — | — | US | disclosed |
| US-20060160882-A1 | Indoline derivatives | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| US-20020169198-A1 | Thio-oxindole derivatives | WYETH (US) | 2002-11-14 | — | — | US | disclosed |
| US-6462032-B1 | Cyclic regimens utilizing indoline derivatives | WYETH | 2002-10-08 | — | — | US | disclosed |
| US-20020103248-A1 | Thio-oxindole derivatives | WYETH LLC | 2002-08-01 | — | — | US | disclosed |
| US-20020086874-A1 | Indoline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-07-04 | — | — | US | disclosed |
| US-6407101-B1 | PROGESTERONE RECEPTOR ANTAGONISTS; CONTRACEPTIVES, HORMONE REPLACEMENT THERAPY; BREAST AND PROSTATE CANCER TREATMENT; MENOPAUSE | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-18 | — | — | US | disclosed |
| US-20020068735-A1 | Cyanopyrroles | AMERICAN HOME PRODUCTS CORPORATION | 2002-06-06 | — | — | US | disclosed |
| US-6391907-B1 | ANTICANCER AGENTS; CONTRACEPTIVES | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-6355648-B1 | COMPOUNDS AS CONTRACEPTIVES AND PROGESTERONE ANTAGONIST | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-12 | — | — | US | disclosed |
| EP-1175398-A1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | American Home Products Corporation (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066556-A1 | INDOLINE DERIVATIVES AS PROGESTERONE ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039839-A1 | Cyanopyrroles | PGR, MC2R, THRB | PGR 1/4885PDE4A 2009/4885PDE4B 2217/4885 |
| US-20020068735-A1 | Cyanopyrroles | PGR, NR3C2, GNRHR | PGR 1/4885PDE4A 1641/4885PDE4B 1613/4885 |
| US-20070259944-A1 | Indoline derivatives | PGR, GNRHR, PRLHR | PGR 1/4885PDE4A 2487/4885PDE4B 3175/4885 |
| US-20020103248-A1 | Thio-oxindole derivatives | PGR, OXTR, PGRMC1 | PGR 1/4885PDE4A 2297/4885PDE4B 3114/4885 |
| US-20020086874-A1 | Indoline derivatives | PGR, GNRHR, PRLHR | PGR 1/4885PDE4A 3088/4885PDE4B 3647/4885 |
| US-20060160882-A1 | Indoline derivatives | PGR, GNRHR, PRLHR | PGR 1/4885PDE4A 2487/4885PDE4B 3175/4885 |
| US-20020169198-A1 | Thio-oxindole derivatives | GPER1, PGR, ESR1 | PGR 2/4885PDE4A 3580/4885PDE4B 4089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.