Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | UTRN | P46939 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544502 | 0.86 | MAPT (0.47) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL4473598 | 0.85 | ESR1 (0.45) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL4036194 | 0.77 | MAPT (0.57) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL30831338 | 0.77 | MAPT (0.52) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL11934536 | 0.76 | GAA (0.52) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL5226589 | 0.76 | NPC1 (0.68) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL8037820 | 0.75 | MAPT (0.55) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL13771677 | 0.75 | MAPT (0.50) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL12325303 | 0.75 | MPO (0.49) | MAPTALDH1A1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL31239361 | 0.74 | F2RL3 (0.55) | MAPTALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781628-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | Wyeth a Corporation of the State of Delaware (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006026316-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | WYETH (US) | 2006-03-09 | — | — | WO | disclosed |