Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | UTRN | P46939 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.61 |
| ▸ | RELA | Q04206 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12639220 | 0.93 | NPC1 (0.68) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL11828034 | 0.92 | ALDH1A1 (0.71) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL5413693 | 0.91 | ESR1 (0.69) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL18726342 | 0.91 | RAB9A (0.69) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL4032178 | 0.91 | MAPT (0.60) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL28559369 | 0.90 | SMN1; SMN2 (0.66) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL11138585 | 0.90 | HDAC6 (0.58) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL9858278 | 0.90 | HDAC6 (0.58) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL1024034 | 0.89 | HSD17B10 (0.78) | NPC1RAB9AALDH1A1MAPTHDAC6 | |
| SCHEMBL2246136 | 0.89 | ALDH1A1 (0.78) | NPC1RAB9AALDH1A1MAPTHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781628-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | Wyeth a Corporation of the State of Delaware (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006026316-A2 | PRODRUG SUBSTITUTED BENZOXAZOLES AS ESTROGENIC AGENTS | WYETH (US) | 2006-03-09 | — | — | WO | disclosed |