Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.60 |
| ▸ | GHSR | Q92847 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.49 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | CNKSR1 | Q969H4 | 2/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2870078 | 0.83 | RXFP1 (0.52) | RXFP1PFKFB3GHSRMAPTCAPN1 | |
| SCHEMBL12335544 | 0.81 | RXFP1 (0.59) | RXFP1PFKFB3GHSRMLNRCYP2D6 | |
| SCHEMBL29254391 | 0.80 | RXFP1 (1.00) | RXFP1PFKFB3GHSRCYP2D6CNKSR1 | |
| SCHEMBL12334571 | 0.79 | RXFP1 (0.57) | RXFP1PFKFB3GHSRMLNRCYP2D6 | |
| SCHEMBL13633888 | 0.78 | GABRA1 (0.67) | RXFP1PFKFB3MAPTCYP2D6 | |
| SCHEMBL14014137 | 0.78 | PFKFB3 (0.62) | RXFP1PFKFB3GHSRMAPTMLNR | |
| SCHEMBL788488 | 0.75 | PFKFB3 (1.00) | RXFP1PFKFB3GHSRMAPTMLNR | |
| SCHEMBL5233621 | 0.75 | SMN1; SMN2 (0.53) | MAPT | |
| SCHEMBL5229993 | 0.75 | PPARG (0.55) | PFKFB3MAPT | |
| SCHEMBL5228507 | 0.74 | HTT (0.58) | MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |