Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | TYMS | P04818 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.42 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228928 | 0.88 | MEN1 (0.58) | PPARGTYMSMAPTKMT2AMEN1 | |
| SCHEMBL5232052 | 0.80 | TYMS (0.56) | TYMSMAPTKMT2AMEN1PGR | |
| SCHEMBL5233621 | 0.79 | SMN1; SMN2 (0.53) | MAPTKMT2AMEN1P2RX1ALDH1A1 | |
| SCHEMBL5228507 | 0.78 | HTT (0.58) | MAPTKMT2AMEN1P2RX1ALDH1A1 | |
| SCHEMBL12334559 | 0.77 | HSD11B1 (0.64) | KMT2AMEN1NR1H3 | |
| SCHEMBL12789658 | 0.75 | PPARG (0.64) | PPARGMAPTKMT2AMEN1NR3C1 | |
| SCHEMBL5230095 | 0.75 | PRMT1 (0.52) | TYMSMAPTKMT2AMEN1PGR | |
| SCHEMBL5230563 | 0.75 | RXFP1 (0.66) | MAPTPFKFB3 | |
| SCHEMBL5229344 | 0.75 | HDAC1 (0.51) | PPARGMAPTKMT2AMEN1P2RX1 | |
| SCHEMBL8007621 | 0.73 | TYMS (0.52) | TYMSMAPTKMT2AMEN1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |