Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231678 | 1.00 | THRB (0.43) | THRBTGFBR1MAPK14MAPTKDM4E | |
| SCHEMBL5235089 | 0.91 | TGFBR1 (0.35) | THRBTGFBR1MAPK14MAPT | |
| SCHEMBL5235086 | 0.91 | TGFBR1 (0.35) | THRBTGFBR1MAPK14MAPT | |
| SCHEMBL4486620 | 0.89 | TGFBR1 (0.38) | THRBTGFBR1MAPK14APP | |
| SCHEMBL4486616 | 0.89 | TGFBR1 (0.38) | THRBTGFBR1MAPK14APP | |
| SCHEMBL8336424 | 0.89 | TGFBR1 (0.38) | THRBTGFBR1MAPK14APP | |
| SCHEMBL5234868 | 0.88 | TGFBR1 (0.39) | THRBTGFBR1MAPK14KDM4EALDH1A1 | |
| SCHEMBL5234860 | 0.88 | TGFBR1 (0.39) | THRBTGFBR1MAPK14KDM4EALDH1A1 | |
| SCHEMBL5234939 | 0.88 | TGFBR1 (0.39) | THRBTGFBR1MAPK14ALDH1A1TSHR | |
| SCHEMBL5234933 | 0.88 | TGFBR1 (0.39) | THRBTGFBR1MAPK14ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |