Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232151 | 1.00 | THRB (0.42) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5240531 | 0.88 | CYP1A2 (0.38) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5240528 | 0.88 | CYP1A2 (0.38) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5234868 | 0.88 | TGFBR1 (0.39) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5234860 | 0.88 | TGFBR1 (0.39) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5237953 | 0.86 | CYP1A2 (0.38) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5237961 | 0.86 | CYP1A2 (0.38) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5234770 | 0.84 | CYP1A2 (0.38) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5234762 | 0.84 | CYP1A2 (0.38) | THRBTGFBR1MAPK14CYP1A2LMNA | |
| SCHEMBL5238471 | 0.84 | PDE4A (0.38) | TGFBR1CYP1A2ADAM17FAAHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |