Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MIF | P14174 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5231391 | 0.86 | EGFR (0.53) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL4864274 | 0.84 | MIF (0.45) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL5233087 | 0.80 | TGFBR1 (0.45) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL5231551 | 0.77 | BRD4 (0.44) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL4871867 | 0.76 | TGFBR1 (0.53) | EGFRADORA1ADORA2ATGFBR1CCNE1 | |
| SCHEMBL2035471 | 0.74 | EGFR (0.48) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL9199217 | 0.74 | EGFR (0.60) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL4868403 | 0.74 | MAPK14 (0.56) | EGFRADORA1ADORA2ATGFBR1CCNE1 | |
| SCHEMBL4865701 | 0.74 | EGFR (0.55) | EGFRMEN1KMT2AMIFALDH1A1 | |
| SCHEMBL16296917 | 0.74 | TGFBR1 (0.49) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |