Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP8 | P22894 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5232759 | 0.86 | RAPGEF4 (0.38) | RAPGEF4FFAR4TDP1F2PRSS1 | |
| SCHEMBL5384451 | 0.85 | RAPGEF4 (0.41) | RAPGEF4FFAR4TDP1F2PRSS1 | |
| SCHEMBL3073386 | 0.85 | RAPGEF4 (0.38) | RAPGEF4FFAR4LMNAMAPTHTT | |
| SCHEMBL3461956 | 0.83 | RAPGEF4 (0.39) | RAPGEF4TDP1F2PRSS1PRSS2 | |
| SCHEMBL1290843 | 0.82 | RAPGEF4 (0.38) | RAPGEF4FFAR4TDP1F2PRSS1 | |
| SCHEMBL5230082 | 0.82 | RAPGEF4 (0.45) | RAPGEF4TDP1F2PRSS1PRSS2 | |
| SCHEMBL2968699 | 0.82 | RAPGEF4 (0.38) | RAPGEF4FFAR4TDP1F2PRSS1 | |
| SCHEMBL29489025 | 0.82 | RAPGEF4 (0.38) | RAPGEF4FFAR4TDP1F2PRSS1 | |
| SCHEMBL5234362 | 0.81 | LMNA (0.41) | RAPGEF4FFAR4TDP1LMNACA2 | |
| SCHEMBL1694111 | 0.81 | RAPGEF4 (0.41) | RAPGEF4FFAR4TDP1F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |