SCHEMBL5233167

SCHEMBL5233167

CN(C)CCCOC(COCC[Si](C)(C)C)c1nc2c([nH]1)-c1ccccc1Oc1ccccc1-2

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CACNA1H O95180 1/20 0.32
CACNA1B Q00975 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4692912 0.94 LMNA (0.30)
SCHEMBL4695750 0.92 MAPK1 (0.31)
SCHEMBL4692972 0.92 MAPK1 (0.31)
SCHEMBL4693875 0.89
SCHEMBL4695791 0.86
SCHEMBL4694431 0.86 MAPK1 (0.32)
SCHEMBL4697390 0.82 CACNA1H (0.35) CACNA1HCACNA1B
SCHEMBL5229963 0.82 CACNA1H (0.32) CACNA1HCACNA1B
SCHEMBL4694071 0.82 SIGMAR1 (0.33) CACNA1HCACNA1B
SCHEMBL5229740 0.81 CACNA1H (0.35) CACNA1HCACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1684749-B1 USE OF 1,3-DIAZA-DIBENZO[e,h] AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS GLAXOSMITHKLINE ZAGREB (HR) 2007-09-05 EP claimed