Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 8/20 | 0.55 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.47 |
| ▸ | ME2 | P23368 | 6/20 | 0.47 |
| ▸ | ME1 | P48163 | 6/20 | 0.47 |
| ▸ | ME3 | Q16798 | 6/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16026531 | 0.83 | HRH3 (0.53) | PANK3RORCAOC3ME2ME1 | |
| SCHEMBL27637330 | 0.82 | ME2 (0.53) | PANK3AOC3ME2ME1ME3 | |
| SCHEMBL14367676 | 0.81 | AOC3 (0.47) | PANK3AOC3HRH3MEN1KMT2A | |
| SCHEMBL3978153 | 0.81 | AOC3 (0.52) | PANK3RORCAOC3ME2ME1 | |
| SCHEMBL8252773 | 0.80 | AOC3 (0.48) | PANK3AOC3MEN1KMT2A | |
| SCHEMBL29631001 | 0.80 | AOC3 (0.54) | PANK3RORCAOC3ME2ME1 | |
| SCHEMBL594245 | 0.79 | PANK3 (0.49) | PANK3RORCAOC3ME2ME1 | |
| SCHEMBL29042361 | 0.79 | AOC3 (0.51) | PANK3AOC3ME2ME1ME3 | |
| SCHEMBL29631039 | 0.79 | AOC3 (0.51) | PANK3AOC3ME2ME1ME3 | |
| SCHEMBL26966077 | 0.78 | AOC3 (0.58) | PANK3RORCAOC3ME2ME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | claimed |
| EP-1701946-B1 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI AVENTIS (FR) | 2007-12-19 | — | — | EP | disclosed |
| EP-1701946-A2 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | Sanofi-Aventis (FR) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005070910-A2 | DERIVATIVES OF 1-PIPERAZINE- AND 1-HOMOPIPERAZINE-CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS INHIBITORS OF THE FAAH ENZYME | SANOFI-AVENTIS (FR) | 2005-08-04 | — | — | WO | disclosed |