Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234952 | 1.00 | LOXL2 (0.46) | LOXL2CYP1A2NCF1RAB9AMAPT | |
| SCHEMBL5238056 | 0.89 | CYP1A2 (0.54) | LOXL2CYP1A2NCF1RAB9AMAPT | |
| SCHEMBL5238727 | 0.89 | CYP1A2 (0.54) | LOXL2CYP1A2NCF1RAB9AMAPT | |
| SCHEMBL5238458 | 0.86 | LOXL2 (0.46) | LOXL2CYP1A2NCF1RAB9AMAPT | |
| SCHEMBL5238455 | 0.86 | LOXL2 (0.46) | LOXL2CYP1A2NCF1RAB9AMAPT | |
| SCHEMBL5235015 | 0.86 | LOXL2 (0.43) | LOXL2CYP1A2NCF1FERMT2HDAC3 | |
| SCHEMBL5237802 | 0.86 | CYP1A2 (0.44) | LOXL2CYP1A2NCF1RAB9AGRM4 | |
| SCHEMBL5237502 | 0.86 | LOXL2 (0.43) | LOXL2CYP1A2NCF1FERMT2HDAC3 | |
| SCHEMBL5232556 | 0.81 | LOXL2 (0.46) | LOXL2CYP1A2NCF1GRM4FERMT2 | |
| SCHEMBL5232563 | 0.81 | LOXL2 (0.46) | LOXL2CYP1A2NCF1GRM4FERMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |