Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.43 |
| ▸ | CDK2 | P24941 | 9/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | CCNO | P22674 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18949733 | 0.72 | ALDH1A1 (0.55) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL7506607 | 0.69 | SMN1; SMN2 (0.59) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL16019533 | 0.67 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL3683672 | 0.67 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL19422723 | 0.67 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL10971119 | 0.66 | GFER (0.41) | ALDH1A1HPGDHSD17B10ALOX15MAPT | |
| SCHEMBL122881 | 0.66 | ALDH1A1 (0.52) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL123248 | 0.66 | ALDH1A1 (0.52) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL3462043 | 0.65 | KDM4E (0.63) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 | |
| SCHEMBL3460182 | 0.65 | MAPT (0.49) | ALDH1A1HPGDHSD17B10ALOX15CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100358900-C | Novel compounds | ASTRAZENECA AB (SE) | 2008-01-02 | — | — | CN | disclosed |
| EP-1587809-B1 | THIENOPYRIDAZINONE DERIVATIVE AS MODULATORS OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| US-20060223809-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | ASTRAZENECA AB, A SWEDEN CORPORATION | 2006-10-05 | — | — | US | disclosed |
| US-7064126-B2 | Compounds | ASTRAZENECA AB (SE) | 2006-06-20 | — | — | US | disclosed |
| CN-1761670-A | Novel compounds | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | CN | disclosed |
| US-20060052380-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | ASTRAZENECA AB (SE) | 2006-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223809-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | CD4, IL5, CCR6 | ALDH1A1 1279/4885HPGD 335/4885HSD17B10 1782/4885 |
| US-20060052380-A1 | Thieno [2,3,-d]pyridazin-4(5H)-ones; modulation of autoimmune diseases with T-cell antiproliferatives; antiinflammatory; organ transplant rejection; AIDS; chronic obstructive pulmonary disease (COPD); asthma | CD4, IL5, CCR6 | ALDH1A1 1279/4885HPGD 335/4885HSD17B10 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.