Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TAS1R3 | Q7RTX0 | 13/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 12/20 | 0.47 |
| ▸ | TAS1R2 | Q8TE23 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766128 | 0.91 | TSHR (0.46) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL522175 | 0.90 | TSHR (0.61) | TSHRMAPK1ALDH1A1NPSR1MAPT | |
| SCHEMBL16300563 | 0.88 | TSHR (0.47) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL1719721 | 0.87 | TSHR (0.59) | TSHRMAPK1ALDH1A1NPSR1MAPT | |
| SCHEMBL19478140 | 0.87 | TSHR (0.43) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL9766053 | 0.86 | TSHR (0.42) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19478297 | 0.86 | TSHR (0.42) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL21230677 | 0.86 | TSHR (0.46) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL19478152 | 0.86 | TSHR (0.42) | TSHRMAPK1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7198377 | 0.85 | TSHR (0.57) | TSHRMAPK1ALDH1A1NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840534-B2 | Substituted tricyclic compounds as FGFR inhibitors | INCYTE CORPORATION (US) | 2023-12-12 | — | — | US | disclosed |
| CN-109071410-B | Ester compound and use thereof | 大日本除虫菊株式会社 | 2022-11-01 | — | — | CN | disclosed |
| EP-3746435-B1 | SUBSTITUTED QUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2022-08-03 | — | — | EP | disclosed |
| EP-3746435-B1 | SUBSTITUTED QUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER (US) | 2022-08-03 | — | — | EP | disclosed |
| EP-3746435-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Inc. (US) | 2020-12-09 | — | — | EP | disclosed |
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | PFIZER INC. (US) | 2020-05-26 | — | — | US | disclosed |
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | PFIZER INC. (US) | 2020-05-26 | — | — | US | disclosed |
| WO-2020084847-A1 | ESTER COMPOUND AND USE THEREOF | 住友化学株式会社 | 2020-04-30 | — | — | WO | disclosed |
| WO-2019150305-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDOPYRIMIDINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER INC. (US) | 2019-08-08 | — | — | WO | disclosed |
| US-20190233440-A1 | Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents | PFIZER INC. (US) | 2019-08-01 | — | — | US | disclosed |
| EP-0054360-B1 | FLUOROBENZYL CYCLOPROPANE CARBOXYLATES, THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE AS INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-06-05 | — | — | EP | disclosed |
| US-4486355-A | INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-12-04 | — | — | US | disclosed |
| EP-0032121-B1 | SUBSTITUTED TETRAFLUOROBENZYL ALCOHOLS AND HALIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-05-16 | — | — | EP | disclosed |
| US-4385070-A | CYCLOPROPANE DERIVATIVES AS INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1983-05-24 | — | — | US | disclosed |
| US-4370346-A | INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-01-25 | — | — | US | disclosed |
| EP-0060617-A1 | Fluorobenzyl cyclopropane carboxylates, their preparation, compositions and use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-22 | — | — | EP | disclosed |
| EP-0054360-A2 | Fluorobenzyl cyclopropane carboxylates, their preparation, compositions comprising them and their use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-06-23 | — | — | EP | disclosed |
| EP-0016513-B1 | ESTERS OF HALOGENATED SUBSTITUTED CYCLOPROPANOIC ACIDS, THEIR PREPARATION AND USE AS INSECTICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-06-23 | — | — | EP | disclosed |
| EP-0032121-A2 | Substituted tetrafluorobenzyl alcohols and halides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-07-15 | — | — | EP | disclosed |
| EP-0016513-A2 | Esters of halogenated substituted cyclopropanoic acids, their preparation and use as insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-10-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11840534-B2 | Substituted tricyclic compounds as FGFR inhibitors | FGFR3, FGFR1, FGFR2 | TSHR 2765/4885MAPK1 2043/4885TAS1R3 2821/4885 |
| US-10662204-B2 | Substituted quinazoline and pyridopyrimidine derivatives useful as anticancer agents | DPYD, PDXK, TYMP | TSHR 4393/4885MAPK1 1592/4885TAS1R3 4062/4885 |
| US-20190233440-A1 | Substituted Quinazoline and Pyridopyrimidine Derivatives Useful as Anticancer Agents | DPYD, TYMP, TOP2A | TSHR 4431/4885MAPK1 1693/4885TAS1R3 4429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.