SCHEMBL522175

SCHEMBL522175

COC(=O)c1c(F)c(F)c(C(=O)OC)c(F)c1F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.61
MAPK1 P28482 2/20 0.61
CA12 O43570 3/20 0.48
CA1 P00915 3/20 0.48
CA2 P00918 3/20 0.48
CA7 P43166 3/20 0.48
CA9 Q16790 3/20 0.48
CA14 Q9ULX7 3/20 0.48
MAPT P10636 3/20 0.47
ALDH1A1 P00352 1/20 0.44
NPSR1 Q6W5P4 2/20 0.43
RECQL P46063 1/20 0.42
KDM4E B2RXH2 1/20 0.41
ESR1 P03372 1/20 0.41
CYP3A4 P08684 2/20 0.40
ACHE P22303 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
HPGD P15428 1/20 0.38
KMT2A Q03164 2/20 0.37
HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1719721 0.97 TSHR (0.59) TSHRMAPK1CA12CA1CA2
SCHEMBL7198377 0.95 TSHR (0.57) TSHRMAPK1CA12CA1CA2
SCHEMBL522412 0.92 TSHR (0.53) TSHRMAPK1CA12CA1CA2
SCHEMBL27511609 0.90 TSHR (0.53) TSHRMAPK1CA12CA1CA2
SCHEMBL2878001 0.90 TSHR (0.53) TSHRMAPK1CA12CA1CA2
SCHEMBL523604 0.90 TSHR (0.53) TSHRMAPK1CA12CA1CA2
SCHEMBL14271057 0.88 TSHR (0.52) TSHRMAPK1CA12CA1CA2
SCHEMBL505374 0.88 TSHR (0.52) TSHRMAPK1CA12CA1CA2
SCHEMBL505263 0.88 TSHR (0.52) TSHRMAPK1CA12CA1CA2
SCHEMBL29154303 0.88 TSHR (0.52) TSHRMAPK1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119500248-A Supported metal oxide catalyst and preparation method and application thereof 万华化学集团股份有限公司 2025-02-25 CN claimed
CN-105753705-A Mechanical device for production of dimethyl tetrafluoroterephthalate 江苏维尤纳特精细化工有限公司 2016-07-13 CN claimed
CN-103641686-B Synthetic method of 2,3,5,6-tetrafluoro-1,4-benzenedimethanol LIANYUNGANG CCA CHEMICAL CO LTD 2015-07-01 CN claimed
CN-204385107-U Novel dimethyl tetrafluoroterephthalate production equipment JIANGSU WEUNITE FINE CHEM CO LTD 2015-06-10 CN claimed
CN-103641686-A Synthetic method of 2,3,5,6-tetrafluoro-1,4-benzenedimethanol LIANYUNGANG CCA CHEMICAL CO LTD 2014-03-19 CN claimed
CN-103483199-A Preparation method of tetrafluoroterephthalate ZHEJIANG CHEMSYN PHARM CO LTD 2014-01-01 CN claimed
CN-121021771-A Degradable high-permeability protective glasses material and preparation method thereof 广东金海纳实业有限公司 2025-11-28 CN disclosed
CN-119500248-A Supported metal oxide catalyst and preparation method and application thereof 万华化学集团股份有限公司 2025-02-25 CN disclosed
CN-114751807-B Preparation process of 2,3,5, 6-tetrafluorobenzyl alcohol 忠同科技(大连)有限公司 2023-08-22 CN disclosed
CN-113797977-B Ruthenium catalyst and application thereof 沈阳中化农药化工研发有限公司 2022-11-29 CN disclosed
CN-114751807-A Novel efficient preparation process of 2,3,5, 6-tetrafluorobenzyl alcohol 忠同科技(大连)有限公司 2022-07-15 CN disclosed
CN-113801019-A Method for preparing poly-fluorobenzyl methyl ether 沈阳中化农药化工研发有限公司 2021-12-17 CN disclosed
CN-113797977-A Ruthenium catalyst and application thereof 沈阳中化农药化工研发有限公司 2021-12-17 CN disclosed
CN-101321719-A Process for producing tetrafluoroterephthalic acid difluoride SUMITOMO CHEMICAL CO (JP) 2008-12-10 CN disclosed
CN-101321720-A Method for producing tetrafluoroterephthalic acid difluoride SUMITOMO CHEMICAL CO (JP) 2008-12-10 CN disclosed
EP-1961729-A1 METHOD FOR PRODUCING TETRAFLUOROTEREPHTHALIC ACID DIFLUORIDE Sumitomo Chemical Company, Limited (JP) 2008-08-27 EP disclosed
US-20070213570-A1 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-09-13 US disclosed
CN-101001823-A Process for making halogen substituted benzenedimethanol SUMITOMO CHEMICAL CO (JP) 2007-07-18 CN disclosed
EP-1783108-A1 METHOD FOR PRODUCING HALOGEN-SUBSTITUTED BENZENEDIMETHANOL Sumitomo Chemical Company, Limited (JP) 2007-05-09 EP disclosed
WO-2003042148-A2 PROCESS FOR PRODUCING BISBENZIL COMPOUNDS SHOWA DENKO K. K. (JP) 2003-05-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070213570-A1 reacting a halogen-substituted terephthalic acid diester with a borohydride compound in the presence of an alcohol and a solvent ADH1A, ADH1C, CYP4A11 TSHR 79/4885MAPK1 1460/4885CA12 563/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.