SCHEMBL5237089

SCHEMBL5237089

COCCOc1c(CN2C(=O)c3ccccc3C2=O)n(CC(C)(C)C)c(=O)c2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.40
NPSR1 Q6W5P4 2/20 0.39
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
GABRA2 P47869 1/20 0.36
TSHR P16473 3/20 0.36
PTK2B Q14289 1/20 0.36
RAB9A P51151 2/20 0.35
DPP4 P27487 1/20 0.35
PDE10A Q9Y233 1/20 0.34
CASP3 P42574 1/20 0.34
HPGD P15428 3/20 0.34
POLB P06746 2/20 0.34
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
HSD17B10 Q99714 1/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5232925 0.89 TSHR (0.45) ALDH1A1NPSR1GABRA1GABRG2GABRB3
SCHEMBL5238223 0.83 ALDH1A1 (0.44) ALDH1A1TSHRDPP4HPGDPOLB
SCHEMBL5236956 0.83 DPP4 (0.47) ALDH1A1TSHRDPP4POLBKDM4E
SCHEMBL5237691 0.83 ALDH1A1 (0.44) ALDH1A1TSHRDPP4HPGDPOLB
Hydrochloric Acid SCHEMBL5234967 0.82 DPP4 (0.47) ALDH1A1TSHRDPP4POLBHSD17B10
SCHEMBL5236649 0.81 MEN1 (0.40) TSHRPTK2BRAB9ADPP4PDE10A
SCHEMBL5233781 0.80 HPGD (0.39) ALDH1A1NPSR1TSHRPTK2BRAB9A
SCHEMBL5238745 0.80 RORA (0.40) ALDH1A1NPSR1TSHRPTK2BRAB9A
SCHEMBL5236732 0.80 KDM4E (0.42) TSHRPTK2BRAB9APDE10ACASP3
SCHEMBL5237827 0.79 TSHR (0.42) ALDH1A1NPSR1TSHRPTK2BRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1355886-B1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA PHARMACEUTICAL (JP) 2007-07-11 EP disclosed
US-7034039-B2 Fused heterocyclic compounds TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2006-04-25 US disclosed