Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.34 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237411 | 1.00 | LOXL2 (0.43) | LOXL2CYP1A2TGFBR1MAPK14CYP3A4 | |
| SCHEMBL5236327 | 0.85 | LOXL2 (0.43) | LOXL2CYP1A2TGFBR1CYP3A4CYP2D6 | |
| SCHEMBL5236321 | 0.85 | LOXL2 (0.43) | LOXL2CYP1A2TGFBR1CYP3A4CYP2D6 | |
| SCHEMBL5241086 | 0.85 | LOXL2 (0.43) | LOXL2CYP1A2TGFBR1MAPK14CYP3A4 | |
| SCHEMBL5234647 | 0.85 | LOXL2 (0.45) | LOXL2CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL5234654 | 0.85 | LOXL2 (0.45) | LOXL2CYP1A2CYP3A4CYP2D6HIF1A | |
| Hydrazine SCHEMBL5232960 | 0.84 | CYP1A2 (0.42) | LOXL2CYP1A2TGFBR1MAPK14CYP3A4 | |
| SCHEMBL5237043 | 0.83 | LOXL2 (0.49) | LOXL2CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL5234977 | 0.83 | LOXL2 (0.49) | LOXL2CYP1A2CYP3A4CYP2D6HIF1A | |
| SCHEMBL29959459 | 0.81 | CYP1A2 (0.49) | LOXL2CYP1A2TGFBR1MAPK14CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |