Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237043 | 1.00 | LOXL2 (0.49) | LOXL2CYP1A2ALDH1A1HTTNCF1 | |
| SCHEMBL5238496 | 0.85 | LOXL2 (0.45) | LOXL2CYP1A2ALDH1A1NCF1FERMT2 | |
| SCHEMBL5236870 | 0.85 | LOXL2 (0.45) | LOXL2CYP1A2ALDH1A1NCF1FERMT2 | |
| SCHEMBL5234728 | 0.84 | LOXL2 (0.44) | LOXL2CYP1A2ALDH1A1NCF1FERMT2 | |
| SCHEMBL5237340 | 0.84 | LOXL2 (0.44) | LOXL2CYP1A2ALDH1A1NCF1FERMT2 | |
| SCHEMBL5237411 | 0.83 | LOXL2 (0.43) | LOXL2CYP1A2ALDH1A1HTTNCF1 | |
| SCHEMBL5241086 | 0.83 | LOXL2 (0.43) | LOXL2CYP1A2ALDH1A1HTTNCF1 | |
| SCHEMBL5237494 | 0.83 | LOXL2 (0.43) | LOXL2CYP1A2ALDH1A1HTTNCF1 | |
| SCHEMBL5236321 | 0.83 | LOXL2 (0.43) | LOXL2CYP1A2ALDH1A1HTTNCF1 | |
| SCHEMBL5236327 | 0.83 | LOXL2 (0.43) | LOXL2CYP1A2ALDH1A1HTTNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397364-B1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | LILLY CO ELI (US) | 2007-07-25 | — | — | EP | disclosed |
| US-7087626-B2 | Pyrrole derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| US-20060079680-A1 | Pyrazoloazepine compounds as pharmaceutical agents | ELI LILLY AND COMPANY PATENT DIVISION (US) | 2006-04-13 | — | — | US | disclosed |
| EP-1578749-A2 | PYRAZOLOAZEPINE COMPOUNDS AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004048381-A2 | PYRAZOLOAZEPINE COMPOUNDS AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20040106604-A1 | Novel pyrrole derivatives as pharmaceutical agents | ELI LILLY AND COMPANY | 2004-06-03 | — | — | US | disclosed |
| EP-1397364-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2002094833-A1 | NOVEL PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106604-A1 | Novel pyrrole derivatives as pharmaceutical agents | TGFBR1, SMAD3, TGFBR2 | LOXL2 1933/4885CYP1A2 3968/4885ALDH1A1 2217/4885 |
| US-20060079680-A1 | Pyrazoloazepine compounds as pharmaceutical agents | KCNH1, KCNK5, CYP3A5 | LOXL2 4112/4885CYP1A2 140/4885ALDH1A1 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.