Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5235222 | 0.95 | HTR1A (0.41) | NAMPTRORCHCRTR1HCRTR2DRD2 | |
| SCHEMBL5231455 | 0.94 | NAMPT (0.40) | NAMPTRORCHCRTR1HCRTR2DRD2 | |
| SCHEMBL5230652 | 0.93 | NAMPT (0.42) | NAMPTRORCHCRTR1HCRTR2DRD2 | |
| SCHEMBL5240254 | 0.93 | NPC1 (0.46) | NAMPTRORCHCRTR1HCRTR2DRD2 | |
| SCHEMBL5239318 | 0.92 | NPC1 (0.43) | NAMPTHCRTR1HCRTR2DRD3MAPT | |
| SCHEMBL5230093 | 0.92 | HCRTR1 (0.39) | NAMPTRORCHCRTR1HCRTR2SIGMAR1 | |
| SCHEMBL5233648 | 0.92 | HCRTR1 (0.42) | HCRTR1HCRTR2SIGMAR1TP53NPC1 | |
| SCHEMBL5239914 | 0.91 | HCRTR1 (0.42) | NAMPTRORCHCRTR1HCRTR2SIGMAR1 | |
| SCHEMBL5233573 | 0.90 | HSD17B10 (0.41) | NAMPTHCRTR1HCRTR2DRD2DRD3 | |
| SCHEMBL5231603 | 0.90 | NAMPT (0.41) | NAMPTRORCHCRTR1HCRTR2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |