Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.35 |
| ▸ | CDK2 | P24941 | 9/20 | 0.35 |
| ▸ | CDK4 | P11802 | 4/20 | 0.35 |
| ▸ | CCND1 | P24385 | 4/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 4/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5346225 | 0.82 | L3MBTL1 (0.46) | MEN1KMT2AL3MBTL1CCNE2CCNE1 | |
| Potassium Ion SCHEMBL25246615 | 0.80 | MEN1 (0.34) | MEN1KMT2AL3MBTL1CCNE2CCNE1 | |
| SCHEMBL10590680 | 0.79 | FAAH (0.50) | KMT2AL3MBTL1FAAHCES1SMN1; SMN2 | |
| SCHEMBL7142710 | 0.77 | FAAH (0.37) | MEN1KMT2AL3MBTL1CCNE2CCNE1 | |
| SCHEMBL7142705 | 0.77 | L3MBTL1 (0.35) | MEN1KMT2AL3MBTL1CCNE2CCNE1 | |
| SCHEMBL1983579 | 0.77 | KDM4E (0.42) | L3MBTL1CCNE2CCNE1CDK2CDK4 | |
| SCHEMBL7142719 | 0.75 | CDK2 (0.32) | CCNE2CCNE1CDK2CDK4CCND1 | |
| SCHEMBL1980103 | 0.74 | MAPK1 (0.49) | MEN1KMT2AL3MBTL1NPC1TP53 | |
| SCHEMBL16930689 | 0.74 | — | — | |
| SCHEMBL5339140 | 0.73 | L3MBTL1 (0.34) | L3MBTL1CDK2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812442-A2 | IMIDAZO[1,2-A]PYRAZIN-8-YLAMINES USEFUL AS MODULATORS OF KINASE ACTIVITY | CGI Pharmaceuticals, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| US-20060178367-A1 | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. | 2006-08-10 | — | — | US | claimed |
| WO-2006053121-A2 | IMIDAZO[1 , 2-A] PYRAZIN-8-YLAMINES USEFUL AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | claimed |
| US-6096688-A | Oxazole carboxamide herbicides | AMERICAN CYANAMID COMPANY (US) | 2000-08-01 | — | — | US | claimed |
| EP-1812442-A2 | IMIDAZO[1,2-A]PYRAZIN-8-YLAMINES USEFUL AS MODULATORS OF KINASE ACTIVITY | CGI Pharmaceuticals, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| US-20060178367-A1 | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | CGI PHARMACEUTICALS, INC. | 2006-08-10 | — | — | US | disclosed |
| WO-2006053121-A2 | IMIDAZO[1 , 2-A] PYRAZIN-8-YLAMINES USEFUL AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| US-6096688-A | Oxazole carboxamide herbicides | AMERICAN CYANAMID COMPANY (US) | 2000-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178367-A1 | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof | BTK, SYK, LCK | MEN1 3316/4885KMT2A 650/4885L3MBTL1 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.