Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.68 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | RECQL | P46063 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523930 | 1.00 | MAPT (0.68) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL6070988 | 0.88 | RECQL (0.61) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL5818378 | 0.88 | RECQL (0.61) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL10735227 | 0.86 | MAPT (0.57) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL10735224 | 0.86 | MAPT (0.57) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL13916110 | 0.86 | MAPT (0.64) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL1879896 | 0.85 | MAPT (0.63) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL1879894 | 0.85 | MAPT (0.63) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL525132 | 0.85 | ALDH1A1 (0.67) | MAPTLMNARAB9ANPC1TP53 | |
| SCHEMBL7364611 | 0.85 | ALDH1A1 (0.67) | MAPTLMNARAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028045-A1 | Processes for the Preparation of Indiplon and Intermediates Thereof | GLENMARK GENERICS LTD (IN) | 2012-02-02 | — | — | US | claimed |
| US-20090247751-A1 | PROCESS FOR THE PREPARATION OF ZALEPLON AND AN INTERMEDIATE THEREOF | PIRAMAL HEALTHCARE LIMITED (IN) | 2009-10-01 | — | — | US | claimed |
| US-20250340560-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BEIGENE SWITZERLAND GMBH (CH) | 2025-11-06 | — | — | US | disclosed |
| US-20240254128-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BEIGENE SWITZERLAND GMBH (CH) | 2024-08-01 | — | — | US | disclosed |
| US-20230013862-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BEIGENE SWITZERLAND GMBH (CH) | 2023-01-19 | — | — | US | disclosed |
| US-20230013862-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BEIGENE SWITZERLAND GMBH (CH) | 2023-01-19 | — | — | US | disclosed |
| US-11142528-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators | BEIGENE SWITZERLAND GMBH (CH) | 2021-10-12 | — | — | US | disclosed |
| US-11142528-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators | BEIGENE SWITZERLAND GMBH (CH) | 2021-10-12 | — | — | US | disclosed |
| US-20200148690-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BEONE MEDICINES I GMBH (CH) | 2020-05-14 | — | — | US | disclosed |
| US-20200148690-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BEONE MEDICINES I GMBH (CH) | 2020-05-14 | — | — | US | disclosed |
| US-10570139-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators | BEIGENE SWITZERLAND GMBH (CH) | 2020-02-25 | — | — | US | disclosed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | disclosed |
| US-4963553-A | TREATING COGNITIVE AND NEURAL BEHAVIORAL PROBLEMS IN MAMMALS | AMERICAN CYANAMID CO. (US) | 1990-10-16 | — | — | US | disclosed |
| US-4847256-A | HYPOTENSIVE AGENTS | AMERICAN CYANAMID COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | disclosed |
| US-4654347-A | USEFUL AS ANXIOLYTIC AND ANTIEPILEPTIC AGENTS, SEDATIVE-HYPNOTIC AGENTS AND SKELETAL MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1987-03-31 | — | — | US | disclosed |
| EP-0208846-A1 | [7-(3-Disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1987-01-21 | — | — | EP | disclosed |
| US-4626538-A | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4521422-A | ANTICONVULSANT, ANTIEPILEPTIC AGENTS, SEDATIVES, MUSCLE RELAXANTS | AMERICAN CYANAMID COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0129847-A2 | Aryl and heteroaryl[7-(aryl and heteroaryl)-pyrazolo-[1,5-a]-pyrimidin-3-yl]methanones | AMERICAN CYANAMID COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028045-A1 | Processes for the Preparation of Indiplon and Intermediates Thereof | CYP2D6, HLA-B, HLA-DRB1 | MAPT 4124/4885LMNA 296/4885RAB9A 4617/4885 |
| US-20240254128-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BTK, LCK, SYK | MAPT 4821/4885LMNA 4691/4885RAB9A 2228/4885 |
| US-10570139-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators | BTK, LCK, SYK | MAPT 4821/4885LMNA 4691/4885RAB9A 2228/4885 |
| US-20090247751-A1 | PROCESS FOR THE PREPARATION OF ZALEPLON AND AN INTERMEDIATE THEREOF | SLC30A6, SLC30A7, SLC39A3 | MAPT 3251/4885LMNA 573/4885RAB9A 2983/4885 |
| US-20200148690-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BTK, LCK, SYK | MAPT 4821/4885LMNA 4691/4885RAB9A 2228/4885 |
| US-11142528-B2 | Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators | BTK, LCK, SYK | MAPT 4821/4885LMNA 4691/4885RAB9A 2228/4885 |
| US-20230013862-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BTK, LCK, SYK | MAPT 4821/4885LMNA 4691/4885RAB9A 2228/4885 |
| US-20250340560-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINES AS BRUTON'S TYROSINE KINASE MODULATORS | BTK, LCK, SYK | MAPT 4821/4885LMNA 4691/4885RAB9A 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.