Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | CA9 | Q16790 | 4/20 | 0.43 |
| ▸ | PREP | P48147 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL229029 | 0.84 | CA12 (0.44) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL5235060 | 0.84 | ALDH1A1 (0.46) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL21603046 | 0.82 | MAPK1 (0.46) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL27087776 | 0.82 | LMNA (0.47) | CA12CA1CA9ALDH1A1MAPK1 | |
| SCHEMBL5228156 | 0.82 | TSHR (0.49) | CA12CA1CA9ALDH1A1HTT | |
| SCHEMBL5367354 | 0.81 | AAK1 (0.46) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL5235837 | 0.80 | CA12 (0.42) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL2105999 | 0.79 | MAPT (0.56) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL16069602 | 0.79 | ATM (0.47) | CA12CA1CA9PREPALDH1A1 | |
| SCHEMBL12422253 | 0.79 | MAPK1 (0.47) | CA12CA1CA9PREPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507776-B1 | 2-OXO-1,3,4-TRIHYDROQUINAZOLINYL DERIVATIVES FOR THE TREATMENT OF CELL PROLIFERATION-RELATED DISORDERS | AMGEN INC (US) | 2007-02-28 | — | — | EP | disclosed |