Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5244011 | 0.91 | EPHX2 (0.54) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5243425 | 0.86 | LMNA (0.64) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5241978 | 0.84 | PGR (0.57) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5245513 | 0.84 | PGR (0.48) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5242664 | 0.84 | PGR (0.65) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5244095 | 0.83 | EPHX2 (0.52) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5243161 | 0.83 | PGR (0.57) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5240680 | 0.81 | FEN1 (0.45) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5243228 | 0.81 | ERCC1 (0.45) | PGRLMNAHTTEPHX2PPARG | |
| SCHEMBL5244033 | 0.79 | ERCC1 (0.46) | PGRHTTEPHX2PPARGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | disclosed |