Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MTR | Q99707 | 1/20 | 0.46 |
| ▸ | XIAP | P98170 | 1/20 | 0.46 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26779810 | 0.85 | KDM4E (0.59) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL2021954 | 0.80 | PARP1 (0.41) | ALDH1A1HTT | |
| SCHEMBL30073106 | 0.79 | KDM4E (0.72) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL30073110 | 0.79 | KDM4E (0.72) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL7814145 | 0.77 | ALOX15 (0.65) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL8242914 | 0.77 | KDM4E (0.64) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL31252767 | 0.77 | KDM4E (0.64) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL7850156 | 0.75 | KDM4E (0.54) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL10085286 | 0.74 | KDM4E (0.69) | KDM4EALOX15TSHRSIRT1HTR1A | |
| SCHEMBL741365 | 0.74 | ALOX15 (0.65) | KDM4EALOX15TSHRSIRT1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |