Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 2/20 | 0.57 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29427924 | 1.00 | ALOX15 (0.65) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL2022181 | 0.90 | KDM4E (0.61) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL2019710 | 0.89 | DRD2 (0.61) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL5240140 | 0.88 | DRD3 (0.58) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL5244997 | 0.87 | KDM4E (0.55) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL30073110 | 0.86 | KDM4E (0.72) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL30073106 | 0.86 | KDM4E (0.72) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL25330979 | 0.84 | NPC1 (0.57) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL29630944 | 0.83 | KMT2A (0.60) | ALOX15KDM4ETSHRSIRT1KMT2A | |
| SCHEMBL1466305 | 0.83 | KMT2A (0.60) | ALOX15KDM4ETSHRSIRT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110498759-A | The synthetic method of isoindoline ketone compound | TIANJIN RUILING CHEMICAL CO LTD | 2019-11-26 | — | — | CN | disclosed |
| EP-2486012-A1 | PROCESSES FOR THE PREPARATION OF 2-(1-PHENYLETHYL) ISOINDOLIN-1-ONE COMPOUNDS | Celgene Corporation (US) | 2012-08-15 | — | — | EP | disclosed |
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| WO-2011044479-A1 | PROCESSES FOR THE PREPARATION OF 2-(1-PHENYLETHYL) ISOINDOLIN-1-ONE COMPOUNDS | CELGENE CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | ALOX15 852/4885KDM4E 1876/4885TSHR 2132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.