Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 15/20 | 0.63 |
| ▸ | PPARG | P37231 | 9/20 | 0.63 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5240680 | 0.83 | FEN1 (0.45) | EPHX2PPARGERCC1DNASE1FEN1 | |
| SCHEMBL5243228 | 0.83 | ERCC1 (0.45) | EPHX2PPARGCHRM1ERCC1DNASE1 | |
| SCHEMBL5245102 | 0.82 | EPHX2 (0.50) | EPHX2PPARGKIF11ERCC1DNASE1 | |
| SCHEMBL5241978 | 0.82 | PGR (0.57) | EPHX2PPARGERCC1DNASE1FEN1 | |
| SCHEMBL5243774 | 0.81 | KIF11 (0.49) | EPHX2PPARGKIF11CHRM1 | |
| SCHEMBL5244033 | 0.81 | ERCC1 (0.46) | EPHX2PPARGERCC1DNASE1FEN1 | |
| SCHEMBL22612923 | 0.81 | EPHX2 (0.63) | EPHX2PPARGCHRM1 | |
| SCHEMBL5241468 | 0.80 | EPHX2 (0.55) | EPHX2PPARGKIF11ERCC1DNASE1 | |
| SCHEMBL5241022 | 0.80 | PGR (0.43) | EPHX2PPARGERCC1DNASE1FEN1 | |
| SCHEMBL5245513 | 0.80 | PGR (0.48) | EPHX2PPARGERCC1DNASE1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | disclosed |
| EP-1539708-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024699-A1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-25 | — | — | WO | disclosed |