Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | EEF2K | O00418 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703593 | 0.78 | NPC1 (0.51) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4705357 | 0.77 | NPC1 (0.50) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL5243084 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL4703597 | 0.66 | ALDH1A1 (0.40) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13154828 | 0.66 | KDM4E (0.63) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL14954867 | 0.62 | MAPT (0.64) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL13154843 | 0.61 | KDM4E (0.65) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL15116256 | 0.61 | SMN1; SMN2 (0.65) | KDM4EALDH1A1SMN1; SMN2HSD17B10HTT | |
| SCHEMBL23378351 | 0.61 | NPC1 (0.77) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8388800 | 0.61 | SMN1; SMN2 (0.59) | KDM4EALDH1A1LMNASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863571-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | Shering Corporation (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006098962-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | SCHERING CORPORATION (US) | 2006-09-21 | — | — | WO | disclosed |