Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703597 | 0.78 | ALDH1A1 (0.40) | KDM4EALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL5243082 | 0.76 | KDM4E (0.60) | KDM4EALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL9405015 | 0.71 | MEN1 (0.56) | KDM4EALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL460602 | 0.71 | MEN1 (0.50) | MEN1KMT2AACHEBCHE | |
| SCHEMBL15024799 | 0.67 | MEN1 (0.53) | MEN1KMT2AACHEBCHE | |
| SCHEMBL4703593 | 0.66 | NPC1 (0.51) | KDM4EALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL4705357 | 0.65 | NPC1 (0.50) | KDM4EALDH1A1NPSR1L3MBTL1LMNA | |
| SCHEMBL28469513 | 0.64 | BCHE (0.63) | KDM4EALDH1A1LMNAMAPK1HSD17B10 | |
| SCHEMBL12507984 | 0.61 | MEN1 (0.50) | KDM4ENPSR1LMNAMAPTMEN1 | |
| SCHEMBL10286465 | 0.61 | MEN1 (0.44) | KDM4EALDH1A1L3MBTL1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863571-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | Shering Corporation (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006098962-A1 | COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | SCHERING CORPORATION (US) | 2006-09-21 | — | — | WO | disclosed |