SCHEMBL5243252

SCHEMBL5243252

Cc1ccc(-c2nc3c(C(=O)NC4C5CCN(CC5)C4I)cc(Cl)cc3o2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 6/20 0.46
KCNH2 Q12809 2/20 0.46
MAPT P10636 2/20 0.38
CHRNB2 P17787 6/20 0.37
CHRNA7 P36544 6/20 0.37
CHRNA4 P43681 6/20 0.37
ALDH1A1 P00352 2/20 0.36
HPGD P15428 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
TP53 P04637 2/20 0.36
NPC1 O15118 1/20 0.36
GAA P10253 1/20 0.36
THRB P10828 1/20 0.36
TSHR P16473 1/20 0.36
RAB9A P51151 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
NFKB1 P19838 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5245030 0.83 HTR3A (0.59) HTR3AKCNH2CHRNB2CHRNA7CHRNA4
SCHEMBL5245934 0.83 HTR3A (0.45) HTR3AKCNH2CHRNB2CHRNA7CHRNA4
SCHEMBL5243355 0.83 HTR3A (0.47) HTR3AKCNH2MAPTCHRNB2CHRNA7
SCHEMBL2951056 0.82 HTR3A (0.69) HTR3AKCNH2ALDH1A1TSHR
SCHEMBL5246346 0.81 HTR3A (0.44) HTR3AKCNH2CHRNB2CHRNA7CHRNA4
SCHEMBL5248214 0.81 HTR3A (0.44) HTR3AKCNH2CHRNB2CHRNA7CHRNA4
SCHEMBL5247114 0.81 HTR3A (0.47) HTR3AKCNH2MAPTCHRNB2CHRNA7
SCHEMBL5246447 0.80 HTR3A (0.43) HTR3AKCNH2MAPTCHRNB2CHRNA7
SCHEMBL5245304 0.80 HTR3A (0.43) HTR3AKCNH2CHRNB2CHRNA7CHRNA4
SCHEMBL5244272 0.80 HTR3A (0.44) HTR3AKCNH2MAPTCHRNB2CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1853597-A1 BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D AMR Technology, Inc. (US) 2007-11-14 EP disclosed
WO-2006089100-A1 BENZOXAZOLE CARBOXAMIDES FOR TREATING CINV AND IBS-D AMR TECHNOLOGY, INC. (US) 2006-08-24 WO disclosed