Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2970060 | 0.83 | CTSS (0.43) | CTSLCTSSCTSKEPAS1KLK5 | |
| SCHEMBL5325953 | 0.75 | TRPV1 (0.43) | TP53SMN1; SMN2 | |
| SCHEMBL6503512 | 0.73 | SYK (0.41) | SYKCTSLCTSSCTSKKLK5 | |
| SCHEMBL5372372 | 0.72 | EPAS1 (0.48) | EPAS1TP53 | |
| SCHEMBL2970876 | 0.70 | EPAS1 (0.44) | SYKEPAS1TP53SMN1; SMN2 | |
| SCHEMBL13202519 | 0.69 | CA2 (0.47) | CTSLCTSSCTSKMALT1BRD4 | |
| SCHEMBL12358021 | 0.69 | SYK (0.42) | SYKCTSLCTSSCTSKKLK5 | |
| SCHEMBL15483314 | 0.69 | SYK (0.42) | SYKCTSLCTSSCTSKKLK5 | |
| SCHEMBL14110740 | 0.69 | MEN1 (0.44) | SYKCTSLCTSSCTSKKLK5 | |
| SCHEMBL7655323 | 0.69 | ITGAV (0.44) | SYKCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853573-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | Rigel Pharmaceuticals, Inc. (US) | 2007-11-14 | — | — | EP | claimed |
| WO-2006091858-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | RIGEL PHARMACEUTICALS, INC. (US) | 2006-08-31 | — | — | WO | claimed |