Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.48 |
| ▸ | DNASE1 | P24855 | 1/20 | 0.48 |
| ▸ | FEN1 | P39748 | 1/20 | 0.48 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243046 | 0.89 | ERCC1 (0.52) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5240594 | 0.82 | ERCC1 (0.46) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5857084 | 0.81 | ERCC1 (0.45) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5242577 | 0.81 | ERCC1 (0.44) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL14339623 | 0.78 | LMNA (0.55) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5240740 | 0.74 | MEN1 (0.62) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5242312 | 0.73 | POLB (0.52) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5241978 | 0.72 | PGR (0.57) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5243128 | 0.72 | POLB (0.51) | ERCC1DNASE1FEN1ERCC4APP | |
| SCHEMBL5245528 | 0.72 | ERCC1 (0.51) | ERCC1DNASE1FEN1ERCC4APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | claimed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1539708-B1 | BENZIMIDAZOLONES AND THEIR USE AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-12-26 | — | — | EP | disclosed |
| US-7115644-B2 | Heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-10-03 | — | — | US | disclosed |