Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14303147 | 0.90 | L3MBTL1 (0.67) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4222736 | 0.88 | L3MBTL1 (0.64) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4864670 | 0.84 | L3MBTL1 (0.77) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL26102667 | 0.80 | LMNA (0.69) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL7012242 | 0.78 | LMNA (0.67) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL31643319 | 0.78 | KMT2A (0.67) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL4506781 | 0.78 | KDM4E (0.76) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL3771626 | 0.78 | KMT2A (0.80) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL12946592 | 0.77 | SMN1; SMN2 (0.71) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL744071 | 0.77 | LMNA (0.62) | L3MBTL1SMN1; SMN2LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866315-A1 | 1,2,4-TRIAZOLE DERIVATIVES AND THEIR USE AS OXYTOCIN ANTAGONISTS | Pfizer Limited (GB) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006092731-A1 | 1, 2, 4-TRIAZOLE DERIVATIVES AND THEIR USE AS OXYTOCIN ANTAGONISTS | PFIZER LIMTED (GB) | 2006-09-08 | — | — | WO | disclosed |