Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 7/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5245898 | 0.94 | PPARG (0.40) | ROCK2ROCK1METBRD4PPARG | |
| SCHEMBL5250093 | 0.91 | ROCK2 (0.41) | ROCK2ROCK1BRD4PDE10A | |
| SCHEMBL5247751 | 0.91 | EPHX2 (0.36) | ROCK2ROCK1BRD4PPARG | |
| SCHEMBL5247821 | 0.91 | ROCK2 (0.40) | ROCK2ROCK1HTR7HDAC8MET | |
| SCHEMBL5244462 | 0.90 | MAPT (0.40) | BRD4 | |
| SCHEMBL5244706 | 0.89 | ROCK2 (0.40) | ROCK2ROCK1HTR7BRD4PDE10A | |
| SCHEMBL5244355 | 0.88 | PDE10A (0.40) | ROCK2ROCK1METBRD4PDE10A | |
| SCHEMBL5247070 | 0.88 | ROCK2 (0.41) | ROCK2ROCK1HDAC8BRD4 | |
| SCHEMBL5245935 | 0.88 | ROCK2 (0.41) | ROCK2ROCK1HTR7BRD4PDE10A | |
| SCHEMBL5246709 | 0.88 | ROCK2 (0.42) | ROCK2ROCK1BRD4GLSPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |