Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.70 |
| ▸ | SLC18A3 | Q16572 | 7/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986964 | 0.82 | HSD11B1 (1.00) | HSD11B1SMN1; SMN2CYP2C9ALDH1A1ROCK2 | |
| SCHEMBL2991618 | 0.76 | HSD11B1 (0.60) | HSD11B1ALDH1A1ROCK2 | |
| SCHEMBL2999388 | 0.76 | HSD11B1 (0.60) | HSD11B1ALDH1A1ROCK2 | |
| SCHEMBL2999386 | 0.76 | HSD11B1 (0.60) | HSD11B1ALDH1A1ROCK2 | |
| SCHEMBL3542808 | 0.75 | HSD11B1 (0.84) | HSD11B1SMN1; SMN2ALDH1A1ROCK2 | |
| SCHEMBL3428076 | 0.75 | HSD11B1 (0.55) | HSD11B1SLC18A3ALDH1A1ROCK2 | |
| SCHEMBL16390739 | 0.74 | HSD11B1 (0.74) | HSD11B1SIGMAR1ROCK2 | |
| SCHEMBL2994695 | 0.74 | SIGMAR1 (0.42) | HSD11B1SLC18A3TSHRSIGMAR1 | |
| SCHEMBL3882352 | 0.74 | SIGMAR1 (0.42) | HSD11B1SLC18A3TSHRSIGMAR1 | |
| SCHEMBL3882355 | 0.74 | SIGMAR1 (0.42) | HSD11B1SLC18A3TSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828099-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | Cardimone Pharma Corporation (CA) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006088525-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2006-08-24 | — | — | WO | disclosed |