Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5244276 | 0.98 | MEN1 (0.55) | MEN1CYP2D6KMT2AMGLLNOTUM | |
| SCHEMBL4038817 | 0.83 | MEN1 (0.66) | MEN1CYP2D6KMT2AMGLLOPRD1 | |
| SCHEMBL21775965 | 0.80 | ROCK2 (0.51) | KHKTP53BP1SMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4671332 | 0.80 | MEN1 (0.66) | MEN1CYP2D6KMT2AMGLLSMN1; SMN2 | |
| Bromide SCHEMBL10966281 | 0.78 | MEN1 (0.64) | MEN1CYP2D6KMT2AMGLLALDH1A1 | |
| Hydrochloric Acid SCHEMBL16432330 | 0.78 | MEN1 (0.69) | MEN1CYP2D6KMT2AMGLLALDH1A1 | |
| SCHEMBL5244004 | 0.78 | NPSR1 (0.69) | MEN1KMT2AMGLLNOTUMNPSR1 | |
| SCHEMBL3685970 | 0.77 | PTGS1 (0.62) | MGLLNPSR1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL6208933 | 0.77 | CES2 (0.57) | MEN1CYP2D6KMT2AMGLLOPRD1 | |
| SCHEMBL408318 | 0.77 | KMT2A (0.66) | MEN1CYP2D6KMT2AMGLLHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828130-A2 | HETEROCYCLOALKYL-BENZYL SUBSTITUTED HYDROXYETHLAMINES | Pfizer Products Incorporated (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006064324-A2 | HETEROCYCLOALKYL-BENZYL SUBSTITUTED HYDROXYETHLAMINES | PFIZER PRODUCTS INC. (US) | 2006-06-22 | — | — | WO | disclosed |