Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247381 | 0.96 | PDE5A (0.55) | PDE5AKCNH2 | |
| SCHEMBL5247140 | 0.91 | PDE5A (0.49) | PDE5AKCNH2 | |
| SCHEMBL5245602 | 0.91 | PDE5A (0.49) | PDE5AKCNH2 | |
| SCHEMBL5244083 | 0.90 | PDE5A (0.51) | PDE5AKCNH2 | |
| SCHEMBL5245851 | 0.90 | PDE5A (0.51) | PDE5AKCNH2 | |
| SCHEMBL5247086 | 0.90 | PDE5A (0.53) | PDE5AKCNH2IGF1RKDM4EHSD17B10 | |
| SCHEMBL5244413 | 0.89 | PDE5A (0.56) | PDE5AKCNH2 | |
| SCHEMBL5247942 | 0.87 | PDE5A (0.51) | PDE5AKCNH2 | |
| SCHEMBL5244141 | 0.86 | PDE5A (0.68) | PDE5AKCNH2 | |
| SCHEMBL5249609 | 0.86 | PDE5A (0.68) | PDE5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809632-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006046135-A2 | PYRAZOLO[4,3-D] PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-05-04 | — | — | WO | disclosed |