Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.35 |
| ▸ | RORC | P51449 | 8/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1407295 | 0.76 | NR1H2 (0.48) | NR1H2NR1H3RORCNR1I2NR3C1 | |
| SCHEMBL1407217 | 0.71 | NR1H2 (0.51) | NR1H2NR1H3RORCNR1I2NR3C1 | |
| SCHEMBL5348609 | 0.70 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL5283390 | 0.69 | SOS1 (0.43) | NR1H2NR1H3RORCNR1I2NR3C1 | |
| SCHEMBL1407884 | 0.68 | ROCK2 (0.44) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1407433 | 0.68 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1407309 | 0.67 | NR1H2 (0.44) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1407415 | 0.67 | NR1H2 (0.44) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL3863906 | 0.66 | NR1H2 (0.46) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1414301 | 0.65 | NR1H2 (0.43) | NR1H2NR1H3RORCNR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773781-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006017384-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | WYETH (US) | 2006-02-16 | — | — | WO | disclosed |