Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 5/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 7/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.37 |
| ▸ | ITGAL | P20701 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5300032 | 0.81 | NR1H2 (0.38) | SOS1NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1407362 | 0.75 | NR1H2 (0.52) | SOS1NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL3860036 | 0.74 | NR1H2 (0.66) | SOS1NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL5244461 | 0.73 | ITGB2 (0.40) | SOS1NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1407372 | 0.71 | NR1H2 (0.50) | SOS1NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL5246499 | 0.69 | NR1H2 (0.35) | NR1H2NR1H3NR1I2NR3C1RORC | |
| SCHEMBL1407884 | 0.67 | ROCK2 (0.44) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL5348609 | 0.66 | NR1H2 (0.45) | NR1H2NR1H3NR1I2NR3C1TRPV1 | |
| SCHEMBL1407833 | 0.65 | NR1H2 (0.52) | NR1H2NR1H3NR1I2NR3C1 | |
| SCHEMBL1407587 | 0.65 | NR1H2 (0.52) | NR1H2NR1H3NR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773781-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006017384-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | WYETH (US) | 2006-02-16 | — | — | WO | claimed |