Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5246815 | 0.80 | LMNA (0.58) | LMNAHTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5244234 | 0.79 | LMNA (0.56) | LMNAHTTMAPTSMN1; SMN2DHFR | |
| SCHEMBL5247718 | 0.76 | CDC7 (0.57) | LMNAHTTMAPTSMN1; SMN2DHFR | |
| SCHEMBL3063111 | 0.71 | LMNA (0.59) | LMNAHTTMAPTSMN1; SMN2DHFR | |
| SCHEMBL10914949 | 0.69 | NR1H2 (1.00) | NR1H2LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL29726 | 0.69 | NR1H2 (1.00) | NR1H2LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL719040 | 0.69 | CYP3A4 (0.74) | NR1H2LMNAMAPTDHFRALDH1A1 | |
| SCHEMBL10890396 | 0.67 | NR1H2 (0.93) | NR1H2LMNAMAPTALDH1A1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL28834648 | 0.67 | NR1H2 (0.93) | NR1H2LMNAMAPTALDH1A1CYP3A4 | |
| SCHEMBL28871678 | 0.67 | NR1H2 (0.93) | NR1H2LMNAMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848506-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | Attenuon, LLC (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089298-A2 | PYRIMIDINE-FUSED DIAZEPINE DERIVATIVES AND INDOLE-FUSED PTERIDINES | ATTENUON, LLC (US) | 2006-08-24 | — | — | WO | disclosed |