Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243756 | 0.88 | LMNA (0.33) | LMNAGAAKDM4ERECQL | |
| SCHEMBL4039900 | 0.86 | GAA (0.37) | GAACACNA1GCACNA1HCACNA1I | |
| SCHEMBL8263440 | 0.83 | PDE5A (0.35) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL8262535 | 0.81 | LMNA (0.38) | LMNAGAAKDM4ERECQL | |
| SCHEMBL332176 | 0.81 | CACNA1G (0.33) | GAACACNA1GCACNA1HCACNA1IKDM4E | |
| SCHEMBL4039997 | 0.73 | POLB (0.44) | LMNA | |
| SCHEMBL8262515 | 0.71 | SMN1; SMN2 (0.46) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL333030 | 0.70 | SMN1; SMN2 (0.38) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL8294512 | 0.70 | CACNA1G (0.32) | CACNA1GCACNA1HCACNA1I | |
| SCHEMBL332149 | 0.70 | KDM4E (0.30) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809632-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006046135-A2 | PYRAZOLO[4,3-D] PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-05-04 | — | — | WO | disclosed |