Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.49 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | PDE6D | O43924 | 2/20 | 0.34 |
| ▸ | SCD | O00767 | 1/20 | 0.34 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3905973 | 0.90 | KIF11 (0.51) | KIF11KIF23MC4R | |
| SCHEMBL3962257 | 0.87 | KIF11 (0.65) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5247152 | 0.87 | KIF11 (0.52) | KIF11KIF23MC4RPDE6DMAP1LC3B | |
| SCHEMBL5756154 | 0.86 | KIF11 (0.51) | KIF11KIF23MC4RMAP1LC3BCYP3A4 | |
| SCHEMBL3865232 | 0.83 | KIF11 (0.60) | KIF11KIF23PDE6DMAP1LC3BCYP3A4 | |
| SCHEMBL5250052 | 0.83 | KIF11 (0.40) | KIF11SCD | |
| SCHEMBL3887257 | 0.82 | KIF11 (0.75) | KIF11 | |
| SCHEMBL5739696 | 0.81 | KIF11 (0.55) | KIF11KIF23 | |
| SCHEMBL3957538 | 0.80 | KIF11 (0.55) | KIF11KIF23MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5250049 | 0.80 | KIF11 (0.43) | KIF11MC4RSCDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781674-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTION OF CANCER | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018628-A1 | ENANTIOMERS OF SELECTED FUSED PYRIMIDONES AND USES IN THE TREATMENT AND PREVENTI ON OF CANCER | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |