Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247152 | 0.86 | KIF11 (0.52) | KIF11KCNH2CYP3A4CYP2C19MC4R | |
| SCHEMBL5248554 | 0.86 | KIF11 (0.49) | KIF11KCNH2CYP3A4CYP2C19MC4R | |
| SCHEMBL5756151 | 0.82 | KIF11 (0.60) | KIF11KCNH2CYP3A4CYP2C19KIF23 | |
| SCHEMBL4363439 | 0.77 | KIF11 (0.58) | KIF11 | |
| SCHEMBL4376313 | 0.76 | KIF11 (0.57) | KIF11 | |
| SCHEMBL4366741 | 0.75 | KIF11 (0.54) | KIF11KCNH2CYP3A4CYP2C19KIF23 | |
| SCHEMBL3905973 | 0.75 | KIF11 (0.51) | KIF11MC4RKIF23GNRHR | |
| SCHEMBL5246236 | 0.75 | KIF11 (0.52) | KIF11MC4RKIF23GNRHR | |
| SCHEMBL5756255 | 0.74 | KIF11 (0.51) | KIF11KCNH2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL13956801 | 0.74 | KIF11 (0.64) | KIF11KCNH2CYP3A4CYP2C19KIF23 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |