Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495354 | 0.89 | HTT (0.44) | KMT2AMAPTMEN1ALDH1A1NAMPT | |
| SCHEMBL9499230 | 0.81 | TSHR (0.39) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL5257293 | 0.81 | MEN1 (0.41) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL9496918 | 0.80 | KMT2A (0.42) | KMT2AMEN1ALDH1A1HTTTP53 | |
| SCHEMBL5253142 | 0.79 | MEN1 (0.43) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL9497044 | 0.78 | — | — | |
| SCHEMBL9494438 | 0.75 | EPHX1 (0.40) | KMT2AMAPTMEN1ALDH1A1IDO1 | |
| SCHEMBL5248995 | 0.71 | KMT2A (0.41) | KMT2AMAPTMEN1ALDH1A1IDO1 | |
| SCHEMBL9494589 | 0.70 | NPC1 (0.45) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL5252939 | 0.70 | RAB9A (0.45) | KMT2AMAPTMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1770093-A1 | Pyrido¬2,3-d|pyrimidine derivatives as phosphodiesterase inhibitors | Roche Palo Alto LLC (US) | 2007-04-04 | — | — | EP | disclosed |
| US-5264437-A | Antiinflammatory agents, immunosuppressants or antiallergens | SYNTEX (U.S.A.) INC. (US) | 1993-11-23 | — | — | US | disclosed |