Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5922341 | 0.89 | FFAR1 (0.40) | ALDH1A1LMNAHSD17B10RECQLALOX15 | |
| SCHEMBL3999023 | 0.86 | RAB9A (0.62) | ALDH1A1LMNAHSD17B10RECQLALOX15 | |
| SCHEMBL276357 | 0.80 | MAPT (0.42) | TDP1MAPTTSHR | |
| SCHEMBL21616600 | 0.75 | PTPN1 (0.57) | ALDH1A1LMNAHSD17B10RECQLALOX15 | |
| SCHEMBL8770937 | 0.75 | AOC3 (0.42) | ALDH1A1MAPTHTTHDAC1 | |
| SCHEMBL8770922 | 0.75 | AOC3 (0.42) | LMNATSHRTHRB | |
| SCHEMBL8770939 | 0.75 | NPC1 (0.39) | RECQLNPC1RAB9ASMN1; SMN2HDAC1 | |
| SCHEMBL2633940 | 0.75 | ALDH1A1 (0.67) | ALDH1A1LMNAHSD17B10RECQLALOX15 | |
| SCHEMBL2633915 | 0.75 | ALDH1A1 (0.67) | ALDH1A1LMNAHSD17B10RECQLALOX15 | |
| SCHEMBL2634592 | 0.75 | ALDH1A1 (0.67) | ALDH1A1LMNAHSD17B10RECQLALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1780196-A2 | Pyridine derivatives for use as vanilloid receptor ligands | Amgen, Inc (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1764358-A2 | Cyclic amides as vanilloid receptor ligands and their use in treatments of inflammatory and neuropathic pain | Amgen, Inc (US) | 2007-03-21 | — | — | EP | disclosed |