Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 6/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838722 | 0.85 | PDE7A (0.58) | NSD2PDE7APDE7BCCR4KDM4E | |
| SCHEMBL2840769 | 0.83 | PDE7A (0.56) | NSD2PDE7APDE7BKDM4EALDH1A1 | |
| SCHEMBL2840085 | 0.81 | PDE7A (0.52) | NSD2PDE7APDE7BKDM4EALDH1A1 | |
| SCHEMBL2842652 | 0.77 | NSD2 (0.39) | NSD2KDM4EALDH1A1GAAHPGD | |
| SCHEMBL2833872 | 0.76 | PDE7A (0.39) | NSD2PDE7APDE7BKDM4EALDH1A1 | |
| SCHEMBL2838381 | 0.75 | APP (0.41) | NSD2KMT2A | |
| SCHEMBL2834007 | 0.74 | ALDH1A1 (0.45) | KDM4EALDH1A1GAAHPGDHSD17B10 | |
| SCHEMBL2843182 | 0.74 | SMN1; SMN2 (0.39) | NSD2PDE7APDE7BKDM4EALDH1A1 | |
| SCHEMBL5246234 | 0.71 | HSD17B10 (0.39) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL2843719 | 0.70 | PTGS2 (0.46) | PDE7APDE7BKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590352-B1 | 4-AMINOTHIENO [2,3-d] PYRIMIDINE-6-CARBONITRILE DERIVATIVES AS PDE7 INHIBITORS | ALMIRALL LAB (ES) | 2007-06-27 | — | — | EP | disclosed |