Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 9/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 6/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5141508 | 0.82 | CNR2 (0.59) | CSNK2A1CSNK2A2CSNK2BKMT2ACHEK1 | |
| SCHEMBL5087476 | 0.81 | EGFR (0.49) | CSNK2A1CSNK2A2CSNK2BEGFRMEN1 | |
| SCHEMBL3996140 | 0.77 | TTBK1 (0.56) | TTBK1TTBK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3992608 | 0.75 | TTBK1 (0.53) | TTBK1TTBK2CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL10488935 | 0.75 | EGFR (0.54) | CSNK2A1CSNK2A2CSNK2BEGFRMEN1 | |
| SCHEMBL3993488 | 0.74 | MAPT (0.55) | TTBK1TTBK2ALDH1A1CNR2CNR1 | |
| SCHEMBL30776865 | 0.71 | CSNK2A1 (0.50) | CSNK2A1CSNK2A2CSNK2BEGFRMEN1 | |
| SCHEMBL27133060 | 0.71 | CSNK2A1 (0.50) | CSNK2A1CSNK2A2CSNK2BEGFRMEN1 | |
| SCHEMBL14040932 | 0.70 | TTBK1 (0.56) | TTBK1TTBK2EGFRMEN1KMT2A | |
| SCHEMBL27708736 | 0.69 | MEN1 (0.51) | TTBK1TTBK2CSNK2A1CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753764-A1 | PYRROLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005121140-A1 | PYRROLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |