Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | TEK | Q02763 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248785 | 0.82 | GRM5 (0.37) | GRM5 | |
| SCHEMBL5282164 | 0.79 | ADK (0.38) | MAP4K4 | |
| SCHEMBL403731 | 0.77 | GRM5 (0.61) | GRM5GRM4MAPT | |
| SCHEMBL5492434 | 0.76 | MAPT (0.59) | GRM4MAPT | |
| SCHEMBL2188836 | 0.74 | APP (0.57) | GRM5MAPT | |
| SCHEMBL6293395 | 0.73 | CYP2A6 (0.50) | GRM5 | |
| SCHEMBL4619639 | 0.73 | GRM5 (0.34) | GRM5 | |
| SCHEMBL2182062 | 0.72 | MAP4K4 (0.50) | MAPTMAP4K4 | |
| SCHEMBL3572562 | 0.70 | MAP4K4 (0.53) | GRM5LCKTEKMAP4K4KDR | |
| SCHEMBL5496752 | 0.69 | TSHR (0.46) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737463-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | AstraZeneca AB (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005060970-A1 | PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |