Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 5/20 | 0.38 |
| ▸ | RET | P07949 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.31 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5250409 | 0.79 | GRM5 (0.37) | MAP4K4 | |
| SCHEMBL5492434 | 0.73 | MAPT (0.59) | ADKPIK3CAMTOR | |
| SCHEMBL3583467 | 0.72 | ABL1 (0.51) | ADKRETABL1MAP4K4PIK3CA | |
| SCHEMBL5248785 | 0.72 | GRM5 (0.37) | — | |
| SCHEMBL2188836 | 0.72 | APP (0.57) | MTOR | |
| SCHEMBL4717142 | 0.71 | APP (0.58) | ADKRETPIK3CAMTOR | |
| SCHEMBL17262986 | 0.68 | ADK (0.52) | ADKRETABL1ADORA3ADORA2A | |
| SCHEMBL5496752 | 0.67 | TSHR (0.46) | — | |
| SCHEMBL6293395 | 0.67 | CYP2A6 (0.50) | PIK3CA | |
| SCHEMBL5252136 | 0.67 | ABL1 (0.46) | ADKRETABL1MAP4K4PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863805-A1 | PYRIMIDINE COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006082373-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | WO | disclosed |