Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30337203 | 0.84 | DYRK1A (0.70) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL4402187 | 0.79 | DYRK1A (0.63) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL30935767 | 0.79 | DYRK1A (0.63) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL15649966 | 0.78 | DYRK1A (0.63) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL3545540 | 0.78 | — | — | |
| SCHEMBL2743567 | 0.78 | HSD17B10 (0.43) | KIF11KDM4EERN1S1PR1DRD1 | |
| Hydrochloric Acid SCHEMBL10461111 | 0.77 | DYRK1A (0.61) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL4411668 | 0.76 | DYRK1A (0.60) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL29733143 | 0.76 | DYRK1A (0.60) | MKNK1MKNK2DYRK1APDPK1AAK1 | |
| SCHEMBL2563186 | 0.75 | KMO (0.58) | MKNK1MKNK2KIF11KDM4EERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503757-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-1503757-B1 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2007-12-19 | — | — | EP | disclosed |
| US-7125888-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1503757-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2005-11-16 | — | — | EP | disclosed |
| US-20050176753-A1 | controlling signal transduction; anticancer agents; antitumor agnets; atherosclerosis; vision defects; antidiabetic agents; antiinflammatory agents | MERCK SHARP & DOHME CORP. | 2005-08-11 | — | — | US | disclosed |
| EP-1503757-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003092595-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC (US) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176753-A1 | controlling signal transduction; anticancer agents; antitumor agnets; atherosclerosis; vision defects; antidiabetic agents; antiinflammatory agents | IRAK4, MAP3K4, MAP3K1 | MKNK1 155/4885MKNK2 275/4885DYRK1A 1305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.