Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200412 | 0.84 | PTGDR2 (0.69) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13802269 | 0.82 | PTGDR2 (0.61) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13802268 | 0.82 | PTGDR2 (0.61) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5251986 | 0.82 | PTGDR2 (0.53) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13802266 | 0.81 | PTGDR2 (0.60) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5248719 | 0.79 | PTGDR2 (0.54) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL13802403 | 0.79 | LMNA (0.79) | LMNACYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL1941853 | 0.78 | PTGDR2 (1.00) | PTGDR2 | |
| SCHEMBL13802405 | 0.78 | PTGDR2 (0.70) | PTGDR2PLA2G1BPLA2G2A | |
| SCHEMBL5444376 | 0.77 | PTGDR2 (0.58) | PTGDR2LMNACYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761529-A2 | PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS | Novartis AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005123731-A2 | PYRROLOPYRIDINE DERIVATIVES AND THEIR USE AS CRTH2 ANTAGONISTS | NOVARTIS AG (CH) | 2005-12-29 | — | — | WO | disclosed |